| Event | 2025 Breakthrough Prizes (11th edition) |
| Date | April 5, 2025 |
| Location | Santa Monica, California |
| Established | 2013 by tech luminaries including Mark Zuckerberg and Priscilla Chan |
| Objective | Elevate the status of scientists, reward extraordinary achievements, and inspire the next generation of innovators |
| Breakthrough Prize in Life Sciences | |
| Discovery of Weight-loss Drugs (Ozempic & Wegovy) | Awardees: Daniel J. Drucker, Joel Habener, Jens Juul Holst, Lotte Bjerre Knudsen, Svetlana Mojsov<br>Contribution: Discovered and characterized the hormone GLP-1<br>Significance: Enabled creation of drugs for diabetes and obesity |
| Multiple Sclerosis Research | Awardees: Alberto Ascherio and Stephen L. Hauser<br>Contribution: Identified B-cells as a key factor in MS and linked it to Epstein-Barr virus<br>Significance: Paved the way for targeted MS treatments |
| Gene-editing Technology | Awardee: David R. Liu<br>Contribution: Developed base editing and prime editing tools<br>Significance: Enabled precise DNA editing without cutting the double helix |
| Breakthrough Prize in Fundamental Physics | |
| Awarded to | 13,508 scientists across four CERN LHC collaborations - ALICE, ATLAS, CMS, LHCb |
| Focus | Detailed study of the Higgs boson, strong nuclear forces, and fundamental particles |
| Notable Discoveries | Properties of Higgs boson and symmetry-breaking mechanism, discovery of new strongly interacting particles, explorations of nature under extreme conditions |
| Prize Distribution | $1 million each to ATLAS and CMS, $500,000 each to ALICE and LHCb<br>Use of Funds: Grants for doctoral students via CERN & Society Foundation |
| Breakthrough Prize in Mathematics | |
| Awardee | Dennis Gaitsgory |
| Achievement | Proved the geometric Langlands conjecture |
| Significance | Solved a foundational challenge spanning multiple mathematical disciplines |
| Method | Developed new tools in derived algebraic geometry over 30 years of research |
| Additional Awards | |
| New Horizons Prizes | 6 prizes of $100,000 each, honoured 8 early-career mathematicians and physicists |
| Maryam Mirzakhani New Frontiers Prizes | 3 awards of $50,000 each, given to women PhD mathematicians |
